The 66 Linear Catheter is a minimally invasive sterile single use device intended for Microdialysis monitoring in skin, adipose or resting skeletal muscle tissue. It has a new robust design with a high performance membrane.
The catheter is available with 20,000 or 100,000 Daltons cut off membrane. The 66 Linear Catheter is suitable for many applications due to the linear design and the choice of low or high cut off membranes. It can be used for metabolic research, estimating the free fraction of a drug, pharmacokinetic and pharmacodynamic studies or monitoring inflammatory processes in vivo.
During insertion a standard 21G cannula introducer is inserted through the tissue making an entrance hole and an exit hole. The catheter is inserted into the distal end of the introducer and when the steel cannula is removed the catheter membrane is positioned in the tissue. The unique patented linear design makes the catheter robust and safe to use for several days. The two different dialyzing membranes have excellent diffusion characteristics, allowing a high recovery of substances in the extra cellular fluid. When using the high cut off membrane we recommend to perfuse the catheter with perfusion fluid containing high molecular weight substances for fluid balance and to avoid ultra filtration (e.g 30g Dextran 60/ 1000mL).
The inlet of the catheter is connected to a Microdialysis Pump and samples are regularly collected. The new design gives the opportunity to collect samples in both plastic and glass micro vials. The samples can be analyzed in the ISCUSflex Microdialysis Analyzer for Glucose, Lactate, Pyruvate, Glutamate, Glycerol and Urea or sent to the clinical laboratory for various analyses by methods such as ELISA or HPLC.