Microdialysis is used successfully to address various issues in many different clinical fields, such as monitoring for early detection of secondary brain injuries and flap thrombosis. It is also used in Clinical research applications, such as early indication of transplant rejections and anastomosis leakage.
In clinical pharmacology microdialysis is used as a tool to measure target site concentrations of antibiotics or anticancer drugs in different tissues and organs and to subsequently relate target site PK to PD. Leading university hospitals around the globe use M Dialysis’s clinical solutions for continuous monitoring of specific tissues and organs.
As global drug development costs continue to escalate, partially because of the high attrition rate of development candidates, there is increasing pressure to improve the predictability of clinical outcomes from preclinical studies. By understanding the exposure in the appropriate biophase, as well as the effect of a drug candidate at the site of action, selection and optimal doses of the best compound can be improved.