Bibliography on Clinical Pharmacology

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M Dialysis Att: Katarina Åsberg
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Population Pharmacokinetics of Flucloxacillin In Bone and Soft Tissue- Standard Dosing is Not Sufficient to Achieve Therapeutic Concentrations.

Öbrink-Hansen K, Pham AD, Bue M, Hanberg P, Bendtsen M, Slater J, Friberg LE, Thorsted A, Stilling M.Pharm Res. 2022 Mar 1. doi: 10.1007/s11095-022-03197-y. Online ahead of print.

Monitoring of amoxicilline and ceftazidime in the microdialysate of diabetic foot and serum by capillary electrophoresis with contactless conductivity detection.

Tůma P, Jaček M, Sommerová B, Dlouhý P, Jarošíková R, Husáková J, Wosková V, Fejfarová V.Electrophoresis. 2022 Jan 24. doi: 10.1002/elps.202100366. Online ahead of print.

Microdosing as a Potential Tool to Enhance Clinical Development of Novel Antibiotics: A Tissue and Plasma PK Feasibility Study with Ciprofloxacin.

Oesterreicher Z, Eberl S, Wulkersdorfer B, Matzneller P, Eder C, van Duijn E, Vaes WHJ, Reiter B, Stimpfl T, Jäger W, Nussbaumer-Proell A, Marhofer D, Marhofer P, Langer O, Zeitlinger M.Clin Pharmacokinet. 2022 Jan 7. doi: 10.1007/s40262-021-01091-1. Online ahead of print.

Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue. Hanberg P, Bue M, Kabel J, Jørgensen AR, Jessen C, Søballe K, Stilling M.Acta Orthop. 2021 Dec;92(6):746-752. doi: 10.1080/17453674.2021.1942620. Epub 2021 Aug 2.PMID: 34334093

Target Site Pharmacokinetics of Meropenem: Measurement in Human Explanted Lung Tissue by Bronchoalveolar Lavage, Microdialysis, and Homogenized Lung Tissue. Paal M, Scharf C, Denninger AK, Ilia L, Kloft C, Kneidinger N, Liebchen U, Michel S, Schneider C, Schröpf S, Schuster C, Vogeser M, Weinelt F, Zander J, Zoller M, Schroeder I.Antimicrob Agents Chemother. 2021 Nov 17;65(12):e0156421. doi: 10.1128/AAC.01564-21. Epub 2021 Sep 27

Microdialysis sampling to monitor target-site vancomycin concentrations in septic infants: a feasible way to close the knowledge gap.

Schroepf S, Burau D, Muench HG, Derendorf H, Zeitlinger M, Genzel-Boroviczény O, Adam D, Kloft C.Int J Antimicrob Agents. 2021 Oct;58(4):106405. doi: 10.1016/j.ijantimicag.2021.106405. Epub 2021 Jul 18

Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics.

Busse D, Simon P, Petroff D, Dorn C, Schmitt L, Bindellini D, Kratzer A, Dietrich A, Zeitlinger M, Huisinga W, Michelet R, Wrigge H, Kloft C.Pharmaceutics. 2021 Aug 31;13(9):1380. doi: 10.3390/pharmaceutics13091380

Plasma and Lung Tissue Pharmacokinetics of Ceftaroline Fosamil in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: an In Vivo Microdialysis Study.

Edlinger-Stanger M, Al Jalali V, Andreas M, Jäger W, Böhmdorfer M, Zeitlinger M, Hutschala D.Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0067921. doi: 10.1128/AAC.00679-21. Epub 2021 Jul 19

Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study.

Al Jalali V, Wölfl-Duchek M, Taubert M, Matzneller P, Lackner E, Dorn C, Kratzer A, Wulkersdorfer B, Österreicher Z, Zeitlinger M.J Antimicrob Chemother. 2021 May 29:dkab166. doi: 10.1093/jac/dkab166. Online ahead of print.PMID: 3405065

Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Reponse Exemplified by Levofloxacin.

Busse D, Schaeftlein A, Solms A, Ilia L, Michelet R, Zeitlinger M, Huisinga W, Kloft C.Pharm Res. 2021 Mar;38(3):381-395. doi: 10.1007/s11095-021-02994-1. Epub 2021 Mar 15.PMID: 33723793

Dermatopharmacokinetic and pharmacodynamic evaluation of a novel nanostructured formulation containing capsaicinoids for treating neuropathic pain.

Lorenzoni R, Contri RV, Lima CKF, Barreto F, Araujo BV, Pohlmann AR, de Miranda ALP, Costa TD, Guterres SS.Int J Pharm. 2021 Mar 1;596:120294. doi: 10.1016/j.ijpharm.2021.120294. Epub 2021 Jan 23.PMID: 33497705

Tourniquet-induced ischemia and reperfusion in subcutaneous tissue, skeletal muscle, and calcaneal cancellous bone.

Hanberg P, Bue M, Kabel J, Jørgensen AR, Søballe K, Stilling M.APMIS. 2021 Apr;129(4):225-231. doi: 10.1111/apm.13121.

Immunosuppressant quantification in intravenous microdialysate – towards novel quasi-continuous therapeutic drug monitoring in transplanted patients.

Weber S, Tombelli S, Giannetti A, Trono C, O’Connell M, Wen M, Descalzo AB, Bittersohl H, Bietenbeck A, Marquet P, Renders L, Orellana G, Baldini F, Luppa PB.Clin Chem Lab Med. 2020 Dec 15:cclm-2020-1542. doi: 10.1515/cclm-2020-1542. Online ahead of print

Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy.

Bue M, Sou T, Okkels ASL, Hanberg P, Thorsted A, Friberg LE, Andersson TL, Öbrink-Hansen K, Christensen S.Int J Infect Dis. 2020 Mar;92:133-140. doi: 10.1016/j.ijid.2020.01.010. Epub 2020 Jan 21.

Meropenem Plasma and Interstitial Soft Tissue Concentrations in Obese and Nonobese Patients-A Controlled Clinical Trial.

Simon P, Petroff D, Busse D, Heyne J, Girrbach F, Dietrich A, Kratzer A, Zeitlinger M, Kloft C, Kees F, Wrigge H, Dorn C.Antibiotics (Basel). 2020 Dec 21;9(12):931. doi: 10.3390/antibiotics9120931.

Quantification of microdialysis related variability in humans: Clinical trial design recommendations.

Busse D, Simon P, Michelet R, Ehmann L, Mehner F, Dorn C, Kratzer A, Huisinga W, Wrigge H, Petroff D, Kloft C.Eur J Pharm Sci. 2020 Oct 22:105607. doi: 10.1016/j.ejps.2020.105607. Online ahead of print

Early Antibiotic Prophylaxis Prior to Bypass Surgery Improves Tissue Penetration.

Andreas M, Zeitlinger M, Shabanian S, Wisser W, Thell R, Edlinger-Stanger M, Maier-Salamon A, Jaeger W, Kocher A, Laufer G, Hiesmayr JM, Hutschala D.Thorac Cardiovasc Surg. 2020 Dec;68(8):669-673. doi: 10.1055/s-0039-1695780. Epub 2019 Sep 6

Single-dose pharmacokinetics of temocillin in plasma and soft tissues of healthy volunteers after intravenous and subcutaneous administration: a randomized crossover microdialysis trial.

Matzneller P, Ngougni Pokem P, Capron A, Lackner E, Wulkersdorfer B, Nussbaumer-Pröll A, Österreicher Z, Duchek M, Van de Velde S, Wallemacq PE, Mouton JW, Van Bambeke F, Zeitlinger M.J Antimicrob Chemother. 2020 Sep 1;75(9):2650-2656. doi: 10.1093/jac/dkaa176

Risk of target non-attainment in obese compared to non-obese patients in calculated linezolid therapy.

Ehmann L, Simon P, Busse D, Petroff D, Dorn C, Huisinga W, Dietrich A, Zeitlinger M, Wrigge H, Kloft C.Clin Microbiol Infect. 2020 Apr 18:S1198-743X(20)30214-7. doi: 10.1016/j.cmi.2020.04.009.

Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study.

Simon P, Busse D, Petroff D, Dorn C, Ehmann L, Hochstädt S, Girrbach F, Dietrich A, Zeitlinger M, Kees F, Kloft C, Wrigge H.J Clin Med. 2020 Apr 9;9(4):1067. doi: 10.3390/jcm9041067

Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy.

Bue M, Sou T, Okkels ASL, Hanberg P, Thorsted A, Friberg LE, Andersson TL, Öbrink-Hansen K, Christensen S.Int J Infect Dis. 2020 Mar;92:133-140. doi: 10.1016/j.ijid.2020.01.010. Epub 2020 Jan 21.

Simultaneous Retrodialysis by Drug for Cefuroxime Using Meropenem as an Internal Standard-A Microdialysis Validation Study.

Hanberg P, Bue M, Öbrink-Hansen K, Kabel J, Thomassen M, Tøttrup M, Søballe K, Stilling M.
J Pharm Sci. 2019 Nov 20. pii: S0022-3549(19)30757-9. doi: 10.1016/j.xphs.2019.11.014. [Epub ahead of print]

Bone, Subcutaneous Tissue and Plasma Pharmacokinetics of Cefuroxime in Total Knee Replacement Patients – a Randomized Controlled Trial Comparing Continuous and Short-Term Infusion.

Tøttrup M, Søballe K, Bibby BM, Hardlei TF, Hansen P, Fuursted K, Birke-Sørensen H, Bue M.
APMIS. 2019 Sep 12. doi: 10.1111/apm.12996. [Epub ahead of print

Early Antibiotic Prophylaxis Prior to Bypass Surgery Improves Tissue Penetration.

Andreas M, Zeitlinger M, Shabanian S, Wisser W, Thell R, Edlinger-Stanger M, Maier-Salamon A, Jaeger W, Kocher A, Laufer G, Hiesmayr JM, Hutschala D.
Thorac Cardiovasc Surg. 2019 Sep 6. doi: 10.1055/s-0039-1695780. [Epub ahead of print

Repeated determination of moxifloxacin concentrations in interstitial space fluid of muscle and subcutis in septic patients.

Nowak H, Weidemann C, Martini S, Oesterreicher ZA, Dorn C, Adamzik M, Kees F, Zeitlinger M, Rahmel T.J Antimicrob Chemother. 2019 Jul 12. pii: dkz259. doi: 10.1093/jac/dkz259. [Epub ahead of print]

Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling.

Boisson M, Torres BGS, Yani S, Couet W, Mimoz O, Dahyot-Fizelier C, Marchand S, Grégoire N.
J Antimicrob Chemother. 2019 Jul 1;74(7):1975-1983. doi: 10.1093/jac/dkz139.

In vitro evaluation of an intravenous microdialysis catheter for therapeutic drug monitoring of gentamicin and vancomycin.

van der Mast JE, Nijsten MW, Alffenaar JC, Touw DJ, Bult W.
Pharmacol Res Perspect. 2019 Jun 26;7(4):e00483. doi: 10.1002/prp2.483. eCollection 2019 Aug

Antibiotic exposure at the site of infection: principles and assessment of tissue penetration.

Jager NGL, van Hest RM, Lipman J, Roberts JA, Cotta MO.
Expert Rev Clin Pharmacol. 2019 May 28:1-12. doi: 10.1080/17512433.2019.1621161. [Epub ahead of print]

Measurement of soft tissue drug concentrations in morbidly obese and non-obese patients – A prospective, parallel group, open-labeled, controlled, phase IV, single center clinical trial.

Simon P, Petroff D, Dorn C, Ehmann L, Kloft C, Prettin C, Dietrich A, Zeitlinger M, Kees F, Wrigge H.
Contemp Clin Trials Commun. 2019 May 10;15:100375. doi: 10.1016/j.conctc.2019.100375. eCollection 2019 Sep.    

A population pharmacokineticmodel of intravenous telavancin in healthy individuals to assess tissue exposure.

Ullah S, Matzneller P, Zeitlinger M, Fuhr U, TaubertM.
Naunyn Schmiedebergs Arch Pharmacol. 2019 May 6. doi:10.1007/s00210-019-01647-w. [Epub ahead of print]

Use of microdialysis for the assessment of fluoroquinolone pharmacokinetics in the clinical practice.

Tomas A, Stilinović N, Sabo A, Tomić Z.
Eur J Pharm Sci. 2019 Apr 1;131:230-242. doi: 10.1016/j.ejps.2019.02.032. Epub 2019 Feb 24. Review.

High voriconazole target-site exposure after approved sequence dosing due to nonlinear pharmacokinetics assessed by long-term microdialysis.

Kirbs C, Kluwe F, Drescher F, Lackner E, Matzneller P, Weiss J, Zeitlinger M, Kloft C.
Eur J Pharm Sci. 2019 Apr 1;131:218-229. doi: 10.1016/j.ejps.2019.02.001. Epub 2019 Feb 4

Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial.

Baig S, Veeranna V, Bolton S, Edwards N, Tomlinson JW, Manolopoulos K, Moran J, Steeds RP, Geberhiwot T.
BMC Endocr Disord. 2018 Nov 26;18(1):88. doi: 10.1186/s12902-018-0315-6.

Cefuroxime plasma and tissue concentrations in patients undergoing elective cardiac surgery: Continuous vs bolus application. A pilot study.

Skhirtladze-Dworschak K, Hutschala D, Reining G, Dittrich P, Bartunek A, Dworschak M, Tschernko EM.
Br J Clin Pharmacol. 2019 Jan 12. doi: 10.1111/bcp.13865. [Epub ahead of print

Pharmacokinetic considerations concerning the use of bronchodilators in the treatment of chronic obstructive pulmonary disease.

Matera MG, Rinaldi B, Page C, Rogliani P, Cazzola M.
Expert Opin Drug Metab Toxicol. 2018 Oct;14(10):1101-1111. doi: 10.1080/17425255.2018.1530215. Epub 2018 Oct 9

Plasma and interstitial fluid population pharmacokinetics of vancomycin in critically patients with sepsis.

Abraham J, Sinollareddy M, Roberts MS, Williams P, Peake SL, Lipman J, Roberts JA.
Int J Antimicrob Agents. 2018 Oct 5. pii: S0924-8579(18)30280-2. doi: 10.1016/j.ijantimicag.2018.09.021.

Simultaneous retrodialysis by calibrator for rapid in vivo recovery determination in target site microdialysis.

Yu Y, Chandasana H, Sangari T, Seubert C, Derendorf H.
Journal of pharmaceutical sciences. 2018 Apr 28

Novel in vitro dynamic metabolic system for predicting the human pharmacokinetics of tolbutamide.

Xue CF, Zhang Z, Jin Y, Zhu B, Xing JF, Ma G, Xiang XQ, Cai WM.
Acta pharmacologica Sinica. 2018 Apr 12

Efficacious Cefazolin Prophylactic Dose for Morbidly Obese Women Undergoing Bariatric Surgery Based on Evidence from Subcutaneous Microdialysis and Populational Pharmacokinetic Modeling.

Palma EC, Meinhardt NG, Stein AT, Heineck I, Fischer MI, de Araújo B, Dalla Costa T.
Pharmaceutical research. 2018 Apr 11

Concentrations of cefuroxime in brain tissue of neurointensive care patients.

Hosmann A, Ritscher LC, Burgmann H, Oesterreicher Z, Jäger W, Poschner S, Knosp E, Reinprecht A, Gruber A, Zeitlinger M.
Antimicrob Agents Chemother. 2017 Dec 4. pii: AAC.02164-17. doi: 10.1128/AAC.02164-17.

Moxifloxacin target site concentrations in patients with pulmonary TB utilizing microdialysis: a clinical pharmacokinetic study.

Heinrichs MT, Vashakidze S, Nikolaishvili K, Sabulua I, Tukvadze N, Bablishvili N, Gogishvili S, Little BP, Bernheim A, Guarner J, Peloquin CA, Blumberg HM, Derendorf H, Kempker RR.
J Antimicrob Chemother. 2017 Nov 23. doi: 10.1093/jac/dkx421. [Epub ahead of print

Pharmacokinetics of Cefuroxime in Synovial Fluid.

Schwameis R, Syré S, Marhofer D, Appelt A, Burau D, Sarahrudi K, Kloft C, Zeitlinger M.
Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00992-17. doi: 10.1128/AAC.00992-17. Print 2017 Oct

Bone and subcutaneous adipose tissue pharmacokinetics of vancomycin in total knee replacement patients.

Bue M, Tøttrup M, Hanberg P, Langhoff O, Birke-Sørensen H, Thillemann TM, Andersson TL, Søballe K.
Acta Orthop. 2017 Sep 15:1-6. doi: 10.1080/17453674.2017.1373497. [Epub ahead of print]

Pharmacokinetics and Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers.

Monogue ML, Stainton SM, Baummer-Carr A, Shepard AK, Nugent JF, Kuti JL, Nicolau DP.
Antimicrob Agents Chemother. 2017 Sep 11. pii: AAC.01449-17. doi: 10.1128/AAC.01449-17. [Epub ahead of print]

Microdialysis Monitoring in Clinical Traumatic Brain Injury and Its Role in Neuroprotective Drug Development.

Thelin EP, Carpenter KL, Hutchinson PJ, Helmy A.
AAPS J. 2017 Jan 9. doi: 10.1208/s12248-016-0027-7. [Epub ahead of print]

Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery.

Wittau M, Paschke S, Kurlbaum M, Scheele J, Ly NS, Hemper E, Kornmann M, Henne-Bruns D, Bulitta JB.
Antimicrob Agents Chemother. 2016 Oct 17. pii: AAC.00952-16. Epub ahead of print

Clinical Determinants of Target Non-Attainment of Linezolid in Plasma and Interstitial Space Fluid: A Pooled Population Pharmacokinetic Analysis with Focus on Critically Ill Patients.

Minichmayr IK, Schaeftlein A, Kuti JL, Zeitlinger M, Kloft C.
Clin Pharmacokinet. 2016 Oct 17.

Tissue pharmacokinetics of telavancin in healthy volunteers: a microdialysis study.

Matzneller P, Österreicher Z, Reiter B, Lackner E, Stimpfl T, Zeitlinger M.
J Antimicrob Chemother. 2016 Jul 11. pii: dkw269.

Effects of Topical Tacrolimus and Polyunsaturated Fatty Acids on In Vivo Release of Eicosanoids in Atopic Dermatitis During Dermal Microdialysis.

Quist SR, Wiswedel I, Doering I, Quist J, Gollnick HP.
Acta Derm Venereol. 2016 Feb 25. doi: 10.2340/00015555-2383.

In Vivo Microdialysis To Determine Subcutaneous Interstitial Fluid Penetration and Pharmacokinetics of Fluconazole in Intensive Care Unit Patients with Sepsis.

Sinnollareddy MG, Roberts MS, Lipman J, Lassig-Smith M, Starr T, Robertson T, Peake SL, Roberts JA.
Antimicrob Agents Chemother. 2015 Nov 23;60(2):827-32. doi: 10.1128/AAC

Vancomycin Tissue Pharmacokinetics in Patients with Lower-Limb Infections via In Vivo Microdialysis.

Housman ST, Bhalodi AA, Shepard A, Nugent J, Nicolau DP.
J Am Podiatr Med Assoc. 2015 Sep;105(5):381-8. doi: 10.7547/14-033.PMID: 26429605

Brain-blood ratio: implications in brain drug delivery.

Kulkarni AD, Patel HM, Surana SJ, Belgamwar VS, Pardeshi CV.
Expert Opin Drug Deliv. 2015 Sep 22:1-8. [Epub ahead of print]

Iontophoresis driven concentrations of topically administered diclofenac in skeletal muscle and blood of healthy subjects.

Crevenna R, Burian A, Oesterreicher Z, Lackner E, Jäger W, Rezcicek G, Keilani M, Zeitlinger M.
Eur J Clin Pharmacol. 2015 Aug 14. [Epub ahead of print]

Population Pharmacokinetics and Target Attainment of Meropenem in Plasma and Tissue of Morbidly Obese Patients after Laparoscopic Intraperitoneal Surgery.

Wittau M, Scheele J, Kurlbaum M, Brockschmidt C, Wolf AM, Hemper E, Henne-Bruns D, Bulitta JB.
Antimicrob Agents Chemother. 2015 Oct;59(10):6241-7. doi: 10.1128/AAC.00259-15. Epub 2015 Jul 27

Influence of sustained low-efficiency diafiltration (SLED-f) on interstitial fluid concentrations of fluconazole in a critically ill patient: Use of microdialysis.

Sinnollareddy MG, Roberts MS, Lipman J, Peake SL, Roberts JA.
Int J Antimicrob Agents. 2015 Mar 28. pii: S0924-8579(15)00111-9. doi: 10.1016/j.ijantimicag.2015.02.017

Are interstitial fluid concentrations of meropenem equivalent to plasma concentrations in critically ill patients receiving continuous renal replacement therapy?

Varghese JM, Jarrett P, Wallis SC, Boots RJ, Kirkpatrick CM, Lipman J, Roberts JA.
J Antimicrob Chemother. 2015 Feb;70(2):528-33. doi: 10.1093/jac/dku413. Epub 2014 Oct 21.

Plasma and target-site subcutaneous tissue population pharmacokinetics and dosing simulations of cefazolin in post-trauma critically ill patients.

Roberts JA, Udy AA, Jarrett P, Wallis SC, Hope WW, Sharma R, Kirkpatrick CM, Kruger PS, Roberts MS, Lipman J.
J Antimicrob Chemother. 2015 Jan 20. pii: dku564. [Epub ahead of print]

Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants.

Himebauch AS, Nicolson SC, Sisko M, Moorthy G, Fuller S, Gaynor JW, Zuppa AF, Fox E, Kilbaugh TJ.
J Thorac Cardiovasc Surg. 2014 Dec;148(6):2634-41. doi: 10.1016/j.jtcvs.2014.06.064. Epub 2014 Jul 22

Population pharmacokinetics meets microdialysis: benefits, pitfalls and necessities of new analysis approaches for human microdialysis data.

Schaeftlein A, Minichmayr IK, Kloft C.
Eur J Pharm Sci. 2014 Jun 16;57:68-73. doi: 10.1016/j.ejps.2013.11.004. Epub 2013 Nov 15. Review

Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration.

Varghese JM, Jarrett P, Boots RJ, Kirkpatrick CM, Lipman J, Roberts JA.
Int J Antimicrob Agents. 2014 Feb 10. pii: S0924-8579(14)00023-5. doi: 10.1016/j.ijantimicag.2014.01.009. [Epub ahead of print]

Similar Maximum Systemic but not Local Cyclooxygenase-2 Inhibition by 50 mg Lumiracoxib and 90 mg Etoricoxib: A Randomized Controlled Trial in Healthy Subjects.

Felden L, Walter C, Angioni C, Schreiber Y, von Hentig N, Ferreiros N, Geisslinger G, Lötsch J.
Pharm Res. 2014 Jan 28. [Epub ahead of print]

Role of microdialysis in pharmacokinetics and pharmacodynamics: current status and future directions.

Azeredo FJ, Dalla Costa T, Derendorf H.
Clin Pharmacokinet. 2014 Mar;53(3):205-12. doi: 10.1007/s40262-014-0131-8.

Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis.

Brill MJ, Houwink AP, Schmidt S, Van Dongen EP, Hazebroek EJ, van Ramshorst B, Deneer VH, Mouton JW, Knibbe CA. J Antimicrob Chemother. 2014 Mar;69(3):715-23. doi: 10.1093/jac/dkt444.

Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.

Frasca D, Dahyot-Fizelier C, Adier C, Mimoz O, Debaene B, Couet W, Marchand S.
Antimicrob Agents Chemother. 2014;58(2):1019-23. doi: 10.1128/AAC.01760-13. Epub 2013 Nov 25

Clinical evaluation of extracellular ADMA concentrations in human blood and adipose tissue.

May M, Batkai S, Zörner AA, Tsikas D, Jordan J, Engeli S.
Int J Mol Sci. 2014 Jan 17;15(1):1189-200. doi: 10.3390/ijms15011189.

An exploratory microdialysis study investigating the effect of repeated application of a diclofenac epolamine medicated plaster on prostaglandin concentrations in skeletal muscle after standardized physical exercise.

Burian A, Frangione V, Rovati S, Mautone G, Leuratti C, Vaccani A, Crevenna R, Keilani M, Burian B, Brunner M, Zeitlinger M.Br J Clin Pharmacol. 2013 Dec;76(6):880-7. doi: 10.1111/bcp.12125.

Tissue pharmacokinetics of cefazolin in patients with lower limb infections.

Bhalodi AA, Housman ST, Shepard A, Nugent J, Nicolau DP.
Antimicrob Agents Chemother. 2013 Nov;57(11):5679-83. doi: 10.1128/AAC.01348-13. Epub 2013 Sep 16

Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury.

Dahyot-Fizelier C, Frasca D, Grégoire N, Adier C, Mimoz O, Debaene B, Couet W, Marchand S.
Antimicrob Agents Chemother. 2013 Jun;57(6):2738-42. doi: 10.1128/AAC.02570-12. Epub 2013 Apr 9

Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.

Shannon RJ, Carpenter KL, Guilfoyle MR, Helmy A, Hutchinson PJ.
J Pharmacokinet Pharmacodyn. 2013 Mar 7.

Internal mammary artery harvesting influences antibiotic penetration into presternal tissue.

Andreas M, Zeitlinger M, Hoeferl M, Jaeger W, Zimpfer D, Hiesmayr JM, Laufer G, Hutschala D.
Ann Thorac Surg. 2013 Apr;95(4):1323-30. doi: 10.1016/j.athoracsur.2012.10.088

In vivo pharmacokinetics and in vitro antifungal activity of iodiconazole, a new triazole, determined by microdialysis sampling.

Sun N, Xie Y, Sheng C, Cao Y, Zhang W, Chen H, Fan G. Int J Antimicrob Agents. 2013 Jan 5.

Tissue pharmacokinetics of ertapenem at steady-state in diabetic patients with leg infections.

Sauermann R, Burian B, Burian A, Jäger W, Höferl M, Stella A, Theurer S, Riedl M, Zeitlinger M

Methods to measure target site penetration of antibiotics in critically ill patients.

Schwameis R, Zeitlinger M.
Curr Clin Pharmacol. 2012 Aug 29. [Epub ahead of print

Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms.

Alexander LM, Kutz JL, Kenney WL.
Am J Physiol Regul Integr Comp Physiol. 2012 Nov 28. [Epub ahead of print

Skin and soft tissue concentrations of tedizolid (formerly torezolid), a novel oxazolidinone, following a single oral dose in healthy volunteers.

Sahre M, Sabarinath S, Grant M, Seubert C, Deanda C, Prokocimer P, Derendorf H.
Int J Antimicrob Agents. 2012 Jul;40(1):51-4.

A human vascular model based on microdialysis for the assessment of the vasoconstrictive dose-response effects of norepinephrine and vasopressin in skin.

Folkesson KT, Samuelsson A, Tesselaar E, Dahlström B, Sjöberg F.
Microcirculation. 2012 May;19(4):352-9. doi: 10.1111/j.1549-8719.2012.00170.x

A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.

Carpenter KL, Timofeev I, Nortje J, Czosnyka M, Pickard JD, Hutchinson PJ. Acta Neurochir Suppl. 2012;114:271-6

Determination of tissue penetration and pharmacokinetics of linezolid in patients with diabetic foot infections using in vivo microdialysis.

Wiskirchen DE, Shepard A, Kuti JL, Nicolau DP.
Antimicrob Agents Chemother. 2011 Sep;55(9):4170-5. Epub 2011 Jun 27.

Clinical microdialysis in neuro-oncology: principles and applications.

Goodman JC.
Chin J Cancer. 2011 Mar;30(3):173-81.

The pharmacokinetics of cefazolin in patients undergoing elective & semi-elective abdominal aortic aneurysm open repair surgery.

Douglas A, Altukroni M, Udy AA, Roberts MS, Taraporewalla K, Jenkins J, Lipman J, Roberts JA.
BMC Anesthesiol. 2011 Feb 22;11:5.

Antibiotic dosing in the ‘at risk’ critically ill patient: Linking pathophysiology with pharmacokinetics/pharmacodynamics in sepsis and trauma patients.

Roberts JA, Roberts MS, Semark A, Udy AA, Kirkpatrick CM, Paterson DL, Roberts MJ, Kruger P, Lipman J.
BMC Anesthesiol. 2011 Feb 20;11:3.

Unifying the mathematical modeling of in vivo and in vitro microdialysis.

Bungay PM, Sumbria RK, Bickel U.
J Pharm Biomed Anal. 2011 Apr 28;55(1):54-63. Epub 2011 Jan 19.

A new topical formulation enhances relative diclofenac bioavailability in healthy male subjects.

Brunner M, Davies D, Martin W, Leuratti C, Lackner E, Müller M.
Br J Clin Pharmacol. 2011 Jan 17. doi: 10.1111/j.1365-2125.2011.03914.x. [Epub ahead of print]

Are marketed topical metronidazole creams bioequivalent? Evaluation by in vivo microdialysis sampling and tape stripping methodology.

García Ortiz P, Hansen SH, Shah VP, Sonne J, Benfeldt E.
Skin Pharmacol Physiol. 2011;24(1):44-53. Epub 2010 Sep 16.

Linezolid penetration into wound tissue of two diabetic patients before and after hyperbaric oxygen therapy.

Koomanachai P, Keel RA, Johnson-Arbor KK, Suecof LA, Nicolau DP, Kuti JL.
Undersea Hyperb Med. 2011 Jan-Feb;38(1):11-6.

Are marketed topical metronidazole creams bioequivalent? Evaluation by in vivo microdialysis sampling and tape stripping methodology.

García Ortiz P, Hansen SH, Shah VP, Sonne J, Benfeldt E.
Skin Pharmacol Physiol. 2011;24(1):44-53. Epub 2010 Sep 16.

Linezolid penetration into wound tissue of two diabetic patients before and after hyperbaric oxygen therapy.

Koomanachai P, Keel RA, Johnson-Arbor KK, Suecof LA, Nicolau DP, Kuti JL.
Undersea Hyperb Med. 2011 Jan-Feb;38(1):11-6.

Microdialysis for assessing intratumoral drug disposition in brain cancers: a tool for rational drug development.

Blakeley J, Portnow J.
Expert Opin Drug Metab Toxicol. 2010 Oct 23. [Epub ahead of print]

Linezolid concentrations in infected soft tissue and bone following repetitive doses in diabetic patients with bacterial foot infections.

Traunmüller F, Schintler MV, Spendel S, Popovic M, Mauric O, Scharnagl E, Joukhadar C.
Int J Antimicrob Agents. 2010 Jul;36(1):84-6. Epub 2010 Apr 24.

Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study.

Feuerstein D, Manning A, Hashemi P, Bhatia R, Fabricius M, Tolias C, Pahl C, Ervine M, Strong AJ, Boutelle MG.
J Cereb Blood Flow Metab. 2010 Jul;30(7):1343-55. Epub 2010 Feb 10.

Soft tissue and bone penetration abilities of daptomycin in diabetic patients with bacterial foot infections.

Traunmüller F, Schintler MV, Metzler J, Spendel S, Mauric O, Popovic M, Konz KH, Scharnagl E, Joukhadar C.
J Antimicrob Chemother. 2010 Jun;65(6):1252-7. Epub 2010 Apr 7.

Extracellular concentrations of fosfomycin in lung tissue of septic patients.

Matzi V, Lindenmann J, Porubsky C, Kugler SA, Maier A, Dittrich P, Smolle-Jüttner FM, Joukhadar C.
J Antimicrob Chemother. 2010 May;65(5):995-8. Epub 2010 Mar 12.

Feasibility of microdialysis to determine interstitial rocuronium concentration in the muscle tissue of anesthetized neurosurgical patients.

Fernández-Candil J, Gambús PL, Trocóniz IF, Valero R, Carrero E, Fábregas N.
J Neurosurg Anesthesiol. 2010 Apr;22(2):163-9.

The effect of peripheral enzyme inhibitors on levodopa concentrations in blood and CSF.

Nord M, Zsigmond P, Kullman A, Arstrand K, Dizdar N.
Mov Disord. 2010 Feb 15;25(3):363-7.

The value of the dental impaction pain model in drug development.

Cooper SA, Desjardins PJ.
Methods Mol Biol. 2010;617:175-90.

The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation.

Portnow J, Badie B, Chen M, Liu A, Blanchard S, Synold TW.
Clin Cancer Res. 2009 Nov 15;15(22):7092-8. Epub 2009 Oct 27.

Rapid UPLC-MS/MS method for the determination of ketoprofen in human dermal microdialysis samples.

Tettey-Amlalo RN, Kanfer I.
J Pharm Biomed Anal. 2009 Nov 1;50(4):580-6. Epub 2008 Oct 10.

Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury.

Adamides AA, Rosenfeldt FL, Winter CD, Pratt NM, Tippett NJ, Lewis PM, Bailey MJ, Cooper DJ, Rosenfeld JV.
J Am Coll Surg. 2009 Oct;209(4):531-9. Epub 2009 Jul 9.

Soft tissue penetration of cefuroxime determined by clinical microdialysis in morbidly obese patients undergoing abdominal surgery.

Barbour A, Schmidt S, Rout WR, Ben-David K, Burkhardt O, Derendorf H.
Int J Antimicrob Agents. 2009 Sep;34(3):231-5. Epub 2009 May 2.

High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection.

Schintler MV, Traunmüller F, Metzler J, Kreuzwirt G, Spendel S, Mauric O, Popovic M, Scharnagl E, Joukhadar C.
J Antimicrob Chemother. 2009 Sep;64(3):574-8. Epub 2009 Jul 3.
Application of prolonged microdialysis sampling in carboplatin-treated cancer patients.
Konings IR, Engels FK, Sleijfer S, Verweij J, Wiemer EA, Loos WJ.
Cancer Chemother Pharmacol. 2009 Aug;64(3):509-16. Epub 2008 Dec 20.
Link: ´

Soft-tissue penetration of ceftobiprole in healthy volunteers determined by in vivo microdialysis.

Barbour A, Schmidt S, Sabarinath SN, Grant M, Seubert C, Skee D, Murthy B, Derendorf H.
Antimicrob Agents Chemother. 2009 Jul;53(7):2773-6. Epub 2009 Apr 13.

Multiple-dose pharmacokinetics of telithromycin in peripheral soft tissues.

Traunmüller F, Fille M, Thallinger C, Joukhadar C.
Int J Antimicrob Agents. 2009 Jul;34(1):72-5. Epub 2009 Apr 19.

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.

Roberts JA, Kirkpatrick CM, Roberts MS, Robertson TA, Dalley AJ, Lipman J.
J Antimicrob Chemother. 2009 Jul;64(1):142-50. Epub 2009 Apr 27.

Piperacillin penetration into tissue of critically ill patients with sepsis–bolus versus continuous administration?

Roberts JA, Roberts MS, Robertson TA, Dalley AJ, Lipman J.
Crit Care Med. 2009 Mar;37(3):926-33.

Application of dermal microdialysis for the evaluation of bioequivalence of a ketoprofen topical gel.

Tettey-Amlalo RN, Kanfer I, Skinner MF, Benfeldt E, Verbeeck RK.
Eur J Pharm Sci. 2009 Feb 15;36(2-3):219-25. Epub 2008 Sep 20.

Review on application of microdialysis in medicine study

[Article in Chinese]
Song W, Xu L, Liu J.
Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(3):247-50.

Impact of adult atopic dermatitis on topical drug penetration: assessment by cutaneous microdialysis and tape stripping.

Garcia Ortiz P, Hansen SH, Shah VP, Menné T, Benfeldt E.
Acta Derm Venereol. 2009;89(1):33-8.

Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers.

Dalley AJ, Lipman J, Deans R, Venkatesh B, Rudd M, Roberts MS, Cross SE.
Antimicrob Agents Chemother. 2009 Jan;53(1):210-5. Epub 2008 Oct 27.

Defining the role of macrophages in local moxifloxacin tissue concentrations using biopsy data and whole-body physiologically based pharmacokinetic modelling.

Edginton AN, Ahr G, Willmann S, Stass H.
Clin Pharmacokinet. 2009;48(3):181-7. doi: 10.2165/00003088-200948030-00004.

Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study.

Blakeley JO, Olson J, Grossman SA, He X, Weingart J, Supko JG; New Approaches to Brain Tumor Therapy (NABTT) Consortium.
J Neurooncol. 2009 Jan;91(1):51-8. Epub 2008 Sep 12.

In vivo microdialysis study of the penetration of daptomycin into soft tissues in diabetic versus healthy volunteers.

Kim A, Suecof LA, Sutherland CA, Gao L, Kuti JL, Nicolau DP.
Antimicrob Agents Chemother. 2008 Nov;52(11):3941-6. Epub 2008 Sep 8.

Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo.

Sandberg C, Halldin CB, Ericson MB, Larkö O, Krogstad AL, Wennberg AM.
Br J Dermatol. 2008 Nov;159(5):1170-6. Epub 2008 Aug 19.

The impact of perioperative atelectasis on antibiotic penetration into lung tissue: an in vivo microdialysis study.

Hutschala D, Kinstner C, Skhirtladze K, Mayer-Helm BX, Zeitlinger M, Wisser W, Müller M, Tschernko E.
Intensive Care Med. 2008 Oct;34(10):1827-34. Epub 2008 May 14.

The effect of irritant dermatitis on cutaneous bioavailability of a metronidazole formulation, investigated by microdialysis and dermatopharmacokinetic method.

Ortiz PG, Hansen SH, Shah VP, Menné T, Benfeldt E.
Contact Dermatitis. 2008 Jul;59(1):23-30. Epub 2008 Jun 1.

Tissue and plasma concentrations of antibiotic during cardiac surgery with cardiopulmonary bypass–microdialysis study.

Pojar M, Mandak J, Malakova J, Jokesova I.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Jun;152(1):139-45.

Methods for measuring in-vivo percutaneous absorption in humans.

Kezic S.
Hum Exp Toxicol. 2008 Apr;27(4):289-95.

Pharmacokinetics of meropenem determined by microdialysis in the peritoneal fluid of patients with severe peritonitis associated with septic shock.

Karjagin J, Lefeuvre S, Oselin K, Kipper K, Marchand S, Tikkerberi A, Starkopf J, Couet W, Sawchuk RJ.
Clin Pharmacol Ther. 2008 Mar;83(3):452-9. Epub 2007 Aug 8.

Bioavailability and bioequivalence of topical glucocorticoids.

Wiedersberg S, Leopold CS, Guy RH.
Eur J Pharm Biopharm. 2008 Mar;68(3):453-66. Epub 2007 Aug 8.

A novel way to investigate the effects of plasma exchange on antibiotic levels: use of microdialysis.

Roberts JA, Roberts MS, Robertson TA, Cross SE, Lipman J.
Int J Antimicrob Agents. 2008 Mar;31(3):240-4. Epub 2007 Dec 4.

Effect of severity of sepsis on tissue concentrations of linezolid.

Thallinger C, Buerger C, Plock N, Kljucar S, Wuenscher S, Sauermann R, Kloft C, Joukhadar C.
J Antimicrob Chemother. 2008 Jan;61(1):173-6. Epub 2007 Nov 13.

In vivo methods for the assessment of topical drug bioavailability.

Herkenne C, Alberti I, Naik A, Kalia YN, Mathy FX, Préat V, Guy RH.
Pharm Res. 2008 Jan;25(1):87-103. Epub 2007 Nov 6.

In vivo microdialysis to measure antibiotic penetration into soft tissue during cardiac surgery

Hutschala D, Skhirtladze K, Kinstner C, Mayer-Helm B, Müller M, Wolner E, Tschernko EM.
Ann Thorac Surg. 2007 Nov;84(5):1605-10.

Pitfalls of the application of microdialysis in clinical oncology: controversial findings with docetaxel.

Loos WJ, Zamboni WC, Engels FK, de Bruijn P, Lam MH, de Wit R, Verweij J, Wiemer EA.
J Pharm Biomed Anal. 2007 Oct 18;45(2):288-94. Epub 2007 Jul 26.

Ceramide analogue 14S24 selectively recovers perturbed human skin barrier.

Vávrová K, Hrabálek A, Mac-Mary S, Humbert P, Muret P.
Br J Dermatol. 2007 Oct;157(4):704-12. Epub 2007 Aug 17.

Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans.

Moro C, Pillard F, de Glisezinski I, Crampes F, Thalamas C, Harant I, Marques MA, Lafontan M, Berlan M.
Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R612-7. Epub 2007 Jun 6.

Cerebral uptake of drugs in humans.

Upton RN.
Clin Exp Pharmacol Physiol. 2007 Aug;34(8):695-701.

Plasma and tissue pharmacokinetics of epirubicin and Paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer.

Hunz M, Jetter A, Warm M, Pantke E, Tuscher M, Hempel G, Jaehde U, Untch M, Kurbacher C, Fuhr U.
Clin Pharmacol Ther. 2007 May;81(5):659-68. Epub 2007 Feb 14.

Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.

Wake DJ, Stimson RH, Tan GD, Homer NZ, Andrew R, Karpe F, Walker BR.
J Clin Endocrinol Metab. 2007 May;92(5):1848-56. Epub 2007 Feb 27.

Evaluation of skin penetration of topically applied drugs in humans by cutaneous microdialysis: acyclovir vs. salicylic acid.

Klimowicz A, Farfał S, Bielecka-Grzela S.
J Clin Pharm Ther. 2007 Apr;32(2):143-8.

Spatial distribution of cutaneous microvasculature and local drug clearance after drug application on the skin.

Cevc G, Vierl U.
J Control Release. 2007 Mar 12;118(1):18-26. Epub 2006 Oct 25

Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis.

Tomlinson JW, Sherlock M, Hughes B, Hughes SV, Kilvington F, Bartlett W, Courtney R, Rejto P, Carley W, Stewart PM.
J Clin Endocrinol Metab. 2007 Mar;92(3):857-64. Epub 2007 Jan 2.

Tissue and plasma concentrations of cephuroxime during cardiac surgery in cardiopulmonary bypass–a microdialysis study.

Mand’ák J, Pojar M, Maláková J, Lonsk V, Palicka V, Zivný P.
Perfusion. 2007 Mar;22(2):129-36.

Clinical scoring system for the prediction of target site penetration of antimicrobials in patients with sepsis.

Zeitlinger BS, Zeitlinger M, Leitner I, Müller M, Joukhadar C.
Clin Pharmacokinet. 2007;46(1):75-83.

A pilot study testing whether concentrations of levofloxacin in interstitial space fluid of soft tissues may serve as a surrogate for predicting its pharmacokinetics in lung.

Zeitlinger MA, Traunmüller F, Abrahim A, Müller MR, Erdogan Z, Müller M, Joukhadar C.
Int J Antimicrob Agents. 2007 Jan;29(1):44-50.

Bioequivalence of topical formulations in humans: evaluation by dermal microdialysis sampling and the dermatopharmacokinetic method.

Benfeldt E, Hansen SH, Vølund A, Menné T, Shah VP.
J Invest Dermatol. 2007 Jan;127(1):170-8. Epub 2006 Jul 27.


Acute in vivo regulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by insulin and intralipid infusions in humans.

Wake DJ, Homer NZ, Andrew R, Walker BR.
J Clin Endocrinol Metab. 2006 Nov;91(11):4682-8. Epub 2006 Sep 5.

Acyclovir concentrations in the skin of humans after a single oral dose assessed by in vivo cutaneous microdialysis.

Farfal S, Klimowicz A, Bielecka-Grzela S.
Skin Res Technol. 2006 Nov;12(4):228-34.


Sunscreen penetration of human skin and related keratinocyte toxicity after topical application.

Hayden CG, Cross S, Anderson C, Saunders N, Roberts M.
Skin Pharmacology and Physiology 2005;18:170-4


Technical prerequisites for in vivo microdialysis determination of interleukin- 6 in human dermis.
Sjögren F, Svensson C, Anderson C.
British Journal Dermatology 2002;146, 1-8.


Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies.
Thompson JF. Siebert GA. Anissimov YG. Smithers BM. Doubrovsky A. Anderson CD. Roberts MS.
British Journal of Cancer. 85(2):157-65, 2001 Jul 20.


Microdialysis technique as a method to study the percutaneous penetration of methyl nicotinate through excised human skin in vivo.
Boelsma E, Anderson C, Karlsson A, Ponec M.
Pharmaceuticaal Research 2000;17(2):141-7.

The spectrum of inflammatory cell response to dimethyl sulfoxide.
Sjögren F, Anderson C.
Contact Dermatitis  2000;42(4):216-21.

Can tissue drug concentration be monitored by microdialysis during or after isolated limb perfusion for melanoma treatment.
Wu Z, Smithers M, Anderson C, Roberts M.
Melanoma Research  2000;10(1):47-54.


Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
Cross S, Anderson C, Roberts M.
British Journal of Clinical Pharmacology  1998;46:29-35

Cutaneous microdialysis for human in vivo dermal absorption studies.
Anderson C, Andersson T, Boman A.
in:  Roberts MS, Walters KA eds. Dermal Absorption and Toxicity Assessment  Marcel Dekker, 1998


Is there tissue penetration after application of topical salicylate formulations?
Cross S, Anderson C, Thompson M, Roberts M.